10th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 25-27, 2019

Wednesday - September 25, 2019
11:00 – 13:00
Conference check-in and on-site registration
13:00 – 13:15
Opening | Welcome Words
13:15 – 13:45
Cell and tissue mechanics in solid tumors: Hype or progress?
Josef Käs
Leipzig University, Germany
Session I: Cell mechanics
13:45 – 14:15
From molecular interactions to intermediate filament mechanics
Sarah Köster
Georg-August University Göttingen, Germany
14:15 – 14:45
Cell mechanics and cancer dissemination
Jochen Guck  
TU Dresden & MPI for Physics of Light, Erlangen, Germany
14:45 – 15:00
Mechanobiological control of Circular Dorsal Ruffle dynamics
Hans-Günther Döbereiner
University of Bremen, Germany
15:00 – 15:30
Coffee break
15:30 – 16:00
3D shape transitions of active contractile sheets
Anne Bernheim
Ben Gurion University, Israel
16:00 – 16:30
Viscous dissipation in soft substrates affects focal adhesion formation,
cell morphology, and motility

Paul Janmey
University of Pennsylvania, USA
16:30 – 17:00
Viscoelastic properties of cell cortices - implications for cellular adhesion
Andreas Janshoff
Georg-August University Göttingen, Germany
17:00 – 17:15
Tumor heterogeneity - a possible mechanical origin
Tobias Büscher
Forschungszentrum Jülich GmbH
Poster Session with Buffet Dinner | Young Scientist Awards

Thursday - September 26, 2019

Session 2: Cancer cells and tumors in mechanical confinement
09:00 – 09:30
Mechanical heterogeneity in tissues promote rigidity and control cellular invasion
Dapeng Bi
Northeastern University, USA
09:30 – 10:00
Active material properties of dynamic tissues
Frank Jülicher  
MPI for Physics of Complex Systems Dresden, Germany
10:00 – 10:30
3D microenvironment stiffness regulates
tumor spheroid growth and mechanics via p21 and ROCK

Anna Taubenberger
TU Dresden, Germany
10:30 – 11:00
Coffee break
11:00 – 11:30
3D motion of cancer cells in confined space
Timo Betz
University of Münster, Germany
11:30 - 12:00
Extracellular matrix stiffness and transforming growth factor-ß modulates
pancreatic stromal cells' cytoskeletal remodeling

Andreas Stylianou
University of Cyprus, Cyprus
12:00 – 12:30
The role of tissue biophysics in organ selectivity in metastasis
Kandice Tanner
National Cancer Institute, USA
12:30 – 13:30
Lunch buffet
Session 3: Tumor−stroma interaction 
13:30 – 14:00
Adhesion regulated mechanotransduction in cancer
Johanna Ivaska
University of Turku, Finland
14:00 – 14:30
Oxygen in cancer an neovascularization
Sharon Gerecht
Johns Hopkins University, USA
14:30 – 15:00
Organic and inorganic ECM components as synergistic regulators of cancer mechanosignaling
Claudia Fischbach-Teschl
Cornell University, USA
15:00 – 15:30
Fusogenic liposomes as general pass key for RNA-based approaches against cancer
Rudolf Merkel
Forschungszentrum Jülich GmbH


We proudly present "Camerata Bachiensis" !
"Alte Handelsbörse"  ♦ Naschmarkt 1‚ 04109 Leipzig

(see program here)
Convivial gathering for invited speakers 
(boat tour from city harbour to restaurant "Stelzenhaus" & dinner)

Friday - September 27, 2019

Session 4: Cellular mechanosensing
08:45 – 9:15
Adhesion G protein-coupled receptors - Metabotropic force sensors
that shape development and mechanosensation

Tobias Langenhan
Leipzig University, Germany
9:15 – 09:45
EMT-induced cell mechanical changes enhance mitotic rounding strength
Elisabeth Fischer-Friedrich
TU Dresden, Germany
09:45 – 10:00
MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma models
Loredana Spoerri
The University of Queensland, Brisbane, Australia
10:00 – 10:30
Nuclear rupture at high curvature and high rates leads to defects
in DNA repair to affect cell cycle, differentiation, and genome variation

Dennis Discher
University of Pennsylvania, USA
10:30 – 11:00
Coffee break
Session 5: Translational research
11:00 – 11:30
Human tissue culture
Sonja Kallendrusch
Leipzig University, Germany
11:30 – 12:00
Biophysical properties of tumors in vivo
Ingolf Sack
Charité Berlin, Germany
12:00 – 12:15
Collective motion promotes multi-step drug resistance evolution in dense cellular populations
Jona Kayser
University of California, Berkeley, USA
12:15 – 13:30
Lunch buffet
Session 6: Cancer cell migration
13:30 – 14:00
Dissecting cell migration and mechanics by systematic gene editing approaches
Klemens Rottner
Technical University Braunschweig, Germany
14:00 – 14:30
Mechanobiology of epithelial migration, growth and folding
Xavier Trepat
IBEC, Barcelona, Spain
14:30 – 15:00
Collective cell migration and viscoelasticity
Ivana Pajic-Lijakovic
University of Belgrade, Serbia
15:00 – 15:15
Strategies for individual and collective cell migration by heterogeneous cell populations during cancer metastasis
Parag Katira
San Diego State University, San Diego, USA
15:15 – 15:45
Coffee break
15:45 – 16:15
Confinement induces DNA damage causes increased matrix degradation
and invasiveness in duct carcinoma in situ breast cancer cells

Guilherme Nader
Institut Curié, France
16:15 – 16:45
Physical model for cellular self-polarization and
motility in one dimension: single cells and single-file chains

Nir Gov
Weizmann Institute of Science, Israel
16:45 – 17:15
Vimentin provides the mechanical resilience required for amoeboid migration and protection of the nucleus
Franziska Lautenschläger
Saarland University Saarbrücken, Germany
From 18:00 to open end:
Join the party at "Ratstonne" Moritzbastei with buffet and live music!


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