10th Annual Symposium
Physics of Cancer
September 25-27, 2019
|PoC - Physics of Cancer - Annual Symposium|
Oxygen in cancer and neovascularization
Johns Hopkins University, Whiting School of Engineering, Dept. of Chemical & Biomolecular Engineering,, 3400 North Charles Street, Baltimore, MD 21218 Maryland Hall 221, USA
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Oxygen acts as a potent upstream signaling molecule to control a plethora of cell functions and cell fates. In three-dimensional (3D) tissues, the oxygen concentration is not uniformly distributed, but rather a gradient that depends on distance from oxygen-carrying blood vessels. During tissue regeneration, development or uncontrolled growth (ie, tumor), restricted oxygen transport leads to severe hypoxic gradients. In these same tissues, the extracellular matrix (ECM) provides critical support for cell adhesion, proliferation, migration, and morphogenesis. Hydrogels provide a highly controlled 3D environment that is structurally and biomechanically similar to native ECM and can provide a rich biochemical landscape as well as biophysical cues to influence cell behavior. In this talk I will present our recent efforts to develop hydrogel matrices that activate hypoxic signaling pathways and to study how hypoxic signaling induce a myriad of cellular and systemic adaptations. Examples will include interface along stem cell differentiation, vascular assembly and sarcoma metastasis.