10th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 25-27, 2019
Invited Talk
Active material properties of dynamic tissues
Frank Jülicher
Max-Planck-Institute for the Physics of Complex Systems, Nöthnitzer Straße 38 01187 Dresden, Germany
Contact:  | Website
A fundamental question in Biology is to understand the collective organisation of
many cells during morphogenesis. Morphogenesis often involves the dynamic
remodeling of tissues involving cell rearrangements, cell divisions and cell flows.
The fly wing is an important model system for the study of multicellular dynamics
during morphogenesis. The growth of the wing imaginal disk is governed by
characteristic patterns of cell rearrangements and cell shape changes. During
pupal stages, the early fly wing undergoes a spectacular dynamic reorganization
which generates the final shape of the wing. We characterize tissue remodeling
by quantifying the contributions of specific cellular processes such as cell shape
changes, cell neighbor exchanges, cell division and cell extension to the macroscopic
tissue shear. Based on this approach, we develop a physical model for tissue dynamics
and mechanics that captures the essential physics of tissue remodeling.
University of Leipzig  |  Faculty of Physics and Earth Sciences  |  Peter Debye Institute  |  Soft Matter Physics Division
© Soft Matter Physics Division, University of Leipzig. Designed and created by sp design. Imprint & Disclaimer