10th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 25-27, 2019
Invited Talk
Cell mechanics and cancer dissemination
Jochen Guck
TU Dresden, Biotec, Tatzberg 47/49, 01307 Dresden, Germany
Contact:  | Website
It is generally accepted that the mechanical properties of cancer cells are related to their ability to disseminate through the body. While the connection seems obvious, this simplistic view has to be diversified to take into account the time-dependence of cell mechanical properties in light of the mechanical challenges encountered during the different stage of the metastatic cascade. At a minimum, the journey has to be divided into two parts where cells are advected passively through the vasculature and microcirculation and where they actively migrate through tissues. I will present our latest research results related to these two aspects. Overall, the emerging view is that the mechanical properties of cancer cells constitute a possible therapeutic target to interfere with metastasis as the most fatal aspect of the disease.
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