10th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 25-27, 2019
Invited Talk
Biophysical properties of tumors in vivo
Ingolf Sack
Charité Berlin, Department of Radiology, Germany
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Tumor growth is associated with extensive alterations of tissue structures resulting from a number of processes such as neovascularization, accumulation of cells and remodeling of the extracellular matrix. Furthermore, leaky tumor blood vessels and impaired lymphatic drainage lead to interstitial fluid accumulation and elevated hydrostatic pressure. The altered structure and fluid turnover is mirrored by significant changes in the effective shear modulus as can be measured in vivo by MRE. This talk reviews recent approaches to structure- and pressure-sensitive high resolution MRE and outlines potential clinical applications. It will be discussed how mechanics-based image contrast provides insight into the underlying tissue structure in health and disease with emphasis on tumors.
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