10th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 25-27, 2019
Invited Talk
Mechanobiology of epithelial migration, growth and folding
Xavier Trepat1,2
1ICREA - Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain
2Barcelona Institute for Science and Technology (BIST), Barcelona, Spain
Contact:  | Website
Biological processes such as morphogenesis, tissue regeneration, and cancer invasion are driven by collective migration, division, and folding of epithelial tissues. Each of these functions is tightly regulated by mechanochemical networks and ultimately driven by physical forces. I will present maps of cell-cell and cell-extracellular matrix (ECM) forces during cell migration and division in a variety of epithelial models, from the expanding MDCK cluster to the regenerating zebrafish epicardium. These maps revealed that migration and division in growing tissues are jointly regulated. I will also present direct measurements of epithelial traction, tension, and luminal pressure in three-dimensional epithelia of controlled size and shape. By examining epithelial tension over time-scales of hours and for nominal strains reaching 1000%, we establish a remarkable degree of tensional homeostasis mediated by superelastic behavior.
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