10th Annual Symposium
Physics of Cancer
September 25-27, 2019
|PoC - Physics of Cancer - Annual Symposium|
Adhesion regulated mechanotransduction in cancer
Turku Bioscience, University of Turku, Finland
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Tissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions, in conjunction with the actin cytoskeleton, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer, stiffening of the tumor stroma is an instrumental contributor to tumor progression. Tissue stiffness acts as a migration cue in durotaxis and supports cell proliferation in cancerous tissue. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. I will also discuss our recent observations related to how adhesion maturation and increasing tissue stiffness regulate cell migration in a cell type dependent manner.