15th Annual Symposium
Physics of Cancer
Leipzig, Germany
Sept. 30 - Oct. 2, 2024
 


(Preliminary)
  A G E N D A



Monday - September 30, 2024
 
From 10:00
 Conference check-in
13:00 – 13:15
 Opening & Welcome
Session I: Cell and tissue mechanics
13:15 – 13:45
Keynote Speaker

Role of microtubules in axonal degeneration caused by chemotherapeutic agents
Pramod Pullarkat
(Raman Research Institute, Bangalore, India)
13:45 – 14:15
 Invasion and the extracellular matrix: from fibers to mechanotransduction
Hanna Engelke 
(University of Graz, Austria)
14:15 – 14:30
 Contributed Talk - t.b.a.
14:30 – 15:00
 Coffee break
15:00 – 15:30
 Mechanobiology of extracellular matrix fibers in cancer
Viola Vogel
(ETH Zurich, Switzerland)
15:30 – 15:45
 Contributed Talk - t.b.a.
15:45 – 16:15
 How collagen translates mechanical forces to oxidative stress
Debora Monego
(Heidelberg Institute for Theoretical Studies, Germany)
16:15 – 16:45
 Coffee break
16:45 – 17:00
 Contributed Talk - t.b.a.
17:00 – 17:30
 Mechanotransduction at cell-cell junctions: beyond the usual suspects
Alexander Dunn
(Stanford University, USA)
17:30 – 18:00
 Stiff matrix indues exosome secretion to promote tumor growth
Wei Guo
(University of Pennsylvania, USA)
from 18:00
Social event with buffet dinner

Special Guests: "Hot Club d`Allemagne"



Tuesday - October 1, 2024

Session II: Intermediate filaments
09:00 – 09:30
Keynote Speaker

Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity
Alison Patteson
(Syracuse University, USA)
09:30 – 10:00
 Consequences of intermediate filament´s influence on glioblastoma cell mechanics
Sandrine Etienne-Manneville
(Institut Pasteur, France)
10:00 – 10:15
 Contributed Talk - t.b.a.
10:15 – 10:45
 Coffee break
10:45 – 11:15
 Mechanobiology of a 3D cell culture model of breast gland morphogenesis and invasive transition
Rudolf Merkel
(Forschungszentrum Jülich, Germany)
11:15 – 11:30
 Contributed Talk - t.b.a.
11:30 – 12:00
 Strength and rheology of epithelial tissues
Alexandre Kabla
(University of Cambridge, UK)
12:00 – 12:30
 The intermediate filament code: determinant of emergent collective cell behavior
Rudolf Leube
(University Hospital Aachen, Germany)
12:30 – 14:00
 Lunch break
14:00 – 14:15
 Contributed Talk - t.b.a.
14:15 – 14:45
 Cytoskeletal integration of intermediate filaments by cytolinkers and spacers
Harald Herrmann
(FAU Erlangen-Nuremberg, Germany)
15:00 – 18:00
P O S T E R S E S S I O N


Wednesday - October 2, 2024

Session III: Innovative ex-vivo cancer models
09:00 – 09:30
 In vivo tumors & ex vivo tumoroids establish physics-driven genetic changes & tumoricidal macrophages
Dennis Discher
(University of Pennsylvania, USA)
09:30 – 10:00
 Tissue slices and tissue slice tandem co-culture models: from ex vivo tumor studies towards specific inhibition of glioma invasion
Achim Aigner
(Leipzig University, Germany)
10:00 – 10:30
 Coffee break
10:30 – 11:00
 Morpho-mechanical properties of prostatic cancer associated fibroblasts reflect patient outcome
Anna Taubenberger
(TU Dresden, Germany)
11:00 – 11:15
 Contributed Talk - t.b.a.
11:15 – 11:45
 Modeling cell interactions in the tumor microenvironment
Erik Danen
(Leiden University, The Netherlands)
11:45 – 12:00
 Contributed Talk - t.b.a.
12:00 – 13:30
 Lunch break
Session IV: Mechanical immune escape mechanisms
13:30 – 14:00
Keynote Speaker

Mechanobiology of cytototoxic lymphocyte-mediated solid tumour rejection
Maté Biro
(EMBL, Australia)
14:00 – 14:30
 Predicting safety and efficacy of engineered T cells using an ex vivo human model
Emmanuel Donnadieu
(Institut Cochin, France)
14:30 – 14:45
 Contributed Talk - t.b.a.
14:45 – 15:15
 Coffee break
15:15 – 15:45
 3D Multi-omic cellular maps and CAR T cells engineered to infiltrate solid tumors
Denis Wirtz
(Johns Hopkins University, USA)
15:45 – 16:15
 Understanding the link between immune evasion and metastasis: A story of stromal - immune cell interactions in tumor-draining lymph nodes
Angela Riedel
(University of Würzburg)
16:15 – 16:30
 Contributed Talk - t.b.a.
16:30 – 17:00
 Immune cells employ intermittent integrin-mediated traction forces for 3D migration
Christoph Mark
(FAU Erlangen-Nuremberg, Germany)
17:00 – 17:30
 Closing remarks & Young Scientist Awards
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