15th "Physics of Cancer" Symposium

DFG research group "Multiscale MRE: in vivo physics of cancer (FOR5628)"

11:00 – 11:15	Combined magnetic resonance elastography and 3D MRI deformation mapping for in vivo solid stress assessment in glioblastoma Noah Jaitner (Charité, Germany)
11:15 – 11:30	Magnetic resonance elastography and cell and nucleus shape analysis in zebrafish neuroblastoma models Mareike Wolff (Charité, Germany)
11:30 – 11:45	Automated quantitative histology of colorectal liver metastases to assess tumour response to chemotherapy in correlation with magnetic resonance elastography Kristin Brüggemann (Charité, Germany)
11:45 – 12:00	Assessing the in vivo biophysical properties of tumor and tumor niche using diffusion MRI and MR elastography in an orthotopic HCC mouse model Pedro Augusto Dantas de Moraes (Charité, Germany)
12:00 – 13:15	Small lunch break
Session I: Cell and tissue mechanics

13:15 – 13:45	Opening Talk Biomechanics of Cancer: A Surgical Perspective Karl H. Hillebrandt (Charité, Germany)
13:45 – 14:15	Invasion and the extracellular matrix: from fibers to mechanotransduction Hanna Engelke (University of Graz, Austria)
14:15 – 14:30	Glass transition and dynamic heterogeneity: Perspectives for cancer physics Takeshi Kawasaki (Nagoya University, Japan)
14:30 – 15:00	Coffee break
15:00 – 15:30	Mechanobiology of extracellular matrix fibers in cancer Viola Vogel (ETH Zurich, Switzerland)
15:30 – 15:45	Androgen receptor signaling inhibition enables biophysical changes in prostate cancer associated with increased metastatic potential Clayton Molter (McGill University, Canada)
15:45 – 16:15	How collagen translates mechanical forces to oxidative stress Debora Monego (Max Planck Institute for Polymer Research, Germany)
16:15 – 16:45	Coffee break
16:45 – 17:00	Single cell migration in confined haptotactic gradients Raimon Sunyer (Institute for Bioengineering of Catalonia (IBEC), Spain)
17:00 – 17:30	Mechanotransduction at cell-cell junctions: beyond the usual suspects Alexander Dunn (Stanford University, USA)
17:30 – 18:00	Stiff matrix indues exosome secretion to promote tumor growth Wei Guo (University of Pennsylvania, USA)
from 19:00	Social event with buffet dinner Special guests: "Hot Club d`Allemagne" (We will offer a guided tour to "Assembly Hall"/ Physics faculty building/ first floor, Linnéstr. 5, 04103 Leipzig)

Tuesday - October 1, 2024

Session II: Intermediate filaments

09:00 – 09:30	Keynote Speaker Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity Alison Patteson (Syracuse University, USA)
09:30 – 10:00	Intermediate filaments: from cell mechanics to glioblastoma invasion and therapeutic resistance Sandrine Etienne-Manneville (Institut Pasteur, France)
10:00 – 10:15	Individual and collective force oscillations of cells and cell assemblies in 3D environments David Böhringer (FAU Erlangen-Nuremberg, Germany)
10:15 – 10:45	Coffee break
10:45 – 11:15	Mechanobiology of a 3D cell culture model of breast gland morphogenesis and invasive transition Rudolf Merkel (Forschungszentrum Jülich, Germany)
11:15 – 11:30	Decoding the biomechanome of colorectal cancer Linda Decker (EMBL Heidelberg, Germany)
11:30 – 12:00	Strength and rheology of epithelial tissues Alexandre Kabla (University of Cambridge, UK)
12:00 – 12:30	The intermediate filament code: determinant of emergent collective cell behavior Rudolf Leube (University Hospital Aachen, Germany)
12:30 – 14:00	Lunch break
14:00 – 14:15	Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics Saraswat Bhattacharyya (University of Oxford, GB)
14:15 – 15:00	Videoscreening: HELA ET AL. Tess Marschner, Barcelona (Spain)
15:00 – 18:00	P O S T E R S E S S I O N - Young Scientist Awards -
Listed in alphabetical order
1	Influence of mechanical stress and confinement in the development of time dependent resistance to cisplatin Yasmin Antonelli (Heidelberg University, Germany)
2	Maturation of an epithelial monolayer: molecular crowding as a cue for intracellular viscoelastic rigidification Gregory Arkowitz (Université Paris Cité, France)
3	Self-organized collective invasion of cancer organoids into the extracelular matrix by durolysis Pau Blanco (Universitat Politecnica de Catalunya-BarcelonaTech, Spain)
4	Automated quantitative histology of colorectal liver metastases to assess tumour response to chemotherapy in correlation with magnetic resonance elastography. Kristin Brüggemann (Charité, Germany)
5	Individual and collective force oscillations of cells and cell assemblies in 3D environments David Böhringer (FAU Erlangen-Nuremberg, Germany)
6	Tissue interface crossing by migrating breast cancer cells induces a more aggressive phenotypic characteristics. Cornelia Clemens (Leipzig University, Germany)
7	Effect of fibroblast contractility on immune infiltration in 3D co-culture spheroids of colorectal cancer Eleni Dalaka (IBEC Barcelona, Spain)
8	Assessing the in vivo biophysical properties of tumor and tumor niche using diffusion MRI and MR elastography in an orthotopic HCC mouse model Pedro Augusto Dantas de Moraes (Charité, Germany)
9	Decoding the biomechanome of colorectal cancer Linda Decker (Leipzig University, Germany)
10	Migratory based local cancer cell invasion Dipanwita Dutta (Leipzig University, Germany)
11	Rigid restriction: the aortic wall dilemma Philip Friedrich (Leipzig University, Germany)
12	Exploring glioblastoma organoid complexity with co-localized Brillouin and Raman spectroscopy Roberta Galli (TU Dresden, Germany)
13	Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics Pablo Gottheil (Leipzig University, Germany)
14	Modeling cell contact guidance on alternating stiffness substrates without topographic variations Mathis Grelier (FAU Erlangen-Nuremberg, Germany)
15	Optogenetic control of collective dynamics in epithelial cells Steffen Grosser (IBEC Barcelona, Spain)
16	Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity Minh Tri Ho Thanh (Syracuse University, USA)
17	Immune cells generate traction forces during transient migratory rest periods Natalie Huhn (FAU Erlangen-Nuremberg, Germany)
18	Multiscale morphological analysis of heterogeneity in gastrointestinal cancer patient-derived organoids Sanika Jahagirdar (TU Dresden, Germany)
19	Combined magnetic resonance elastography and 3D MRI deformation mapping for in vivo solid stress assessment in glioblastoma Noah Jaitner (Charité, Germany)
20	Rapid stiffness mapping in soft biologic tissues with micrometer resolution using multifrequency time-harmonic elastography Jakob Jordan (Charité, Germany)
21	Glass transition and dynamic heterogeneity: Perspectives for cancer physics Takeshi Kawasaki (Nagoya University, Japan)
22	Exploring neuroblastoma niche selection: Insights from a zebrafish pseudo-metastasis Model Julia Köppke (Charité, Germany)
23	Confinement and mechanical stress may induce cell heterogeneity and polyploidy in 3D tumoral environments Aldo Leal-Egaña (Heidelberg University, Germany)
24	Plectin mediates cell mechanics across time and length scales Mathilde Lettinga (TU Dresden)
25	oncoGNN: Physics guided geometric deep learning in cancer metastasis Kolya Lettl (Leipzig University, Germany)
26	Growing tumor spheroids from single cells is associated with changes in cell volume and mechanical properties Vaibhav Mahajan (TU Dresden, Germany)
27	The impact of tumor geometry on cancer cell phenotypes Mario Merkel (Leipzig University, Germany)
28	Collagen-hyaluronic hydrogels as a platform to study shear force impact on bladder cancer spheroids Sara Metwally (Institute of Nuclear Physics Polish Academy of Sciences, Poland)
29	Androgen receptor signaling inhibition enables biophysical changes in prostate cancer associated with increased metastatic potential Clayton Molter (McGill University, Canada)
30	Stiff environments promote an aberrant adhesion reinforcement Sergi Olivé (University of Barcelona, Spain)
31	Precision and personalized adaptive hormone control of metastatic prostate cancer Trung Phan (Johns Hopkins University, USA)
32	Shedding light on the HRas-driven basement membrane disruption Eric Platz-Baudin (Forschungszentrum Jülich, Germany)
33	Influence of local anesthetics on the mechanical properties of circulating ovarian cancer cells Salvador Rivera-Moreno (Leipzig University, Germany)
34	Nesting of tumor spheroids Kilian Roth (Leipzig University, Germany)
35	Magnetic Resonance Elastography-derived penetration rate as a biomarker for pre-cancerous liver changes in metabolic dysfunction-associated steatohepatitis Yasmine Safraou (Charité, Germany)
36	ABCG2 facilitates chemotherapeutic resistance via E2f1, E2F2, and E2F3 transcription factors Mohamed A.F.E. Sarhan (Julius-Maximilians-University of Würzburg, Germany)
37	Multiscale biophysical analysis of gastrointestinal cancer patient-derived organoids Vincenzo Maria Schimmenti (Max Planck Institute for the Physics of Complex Systems, Dresden, Germany)
38	Role of vimentin in 3-D migration through differently dense biopolymer networks Lovis Schween (FAU Erlangen-Nuremberg, Germany)
39	Active migration of cancer cells in confinement: A hybrid computational model Saber Shakibi (Utrecht University, The Netherlands)
40	Deciphering immune cell mechanical properties: Towards a better understanding of colitis progression Nadine Ströhlein (Max Planck Institute for the Science of Light and Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany)
41	Single cell migration in confined haptotactic gradients Raimon Sunyer (IBEC Barcelona, Spain)
42	Probing age-dependent mechanical properties of the liver metastatic niche Elke Ulbricht (TU Dresden, Germany)
43	Nucleus position displacement in breast cancer cells Jörg Walter (Leipzig University, Germany)
44	Magnetic resonance elastography and cell and nucleus shape analysis in zebrafish neuroblastoma models Mareike Wolff (Charité, Germany)
45	Glass transition in model cellular systems for the understanding cancer cell Kiwamu Yoshii (Nogoya University, Japan)
46	Mechanical properties of murine microglia in a model of Alzheimer's disease Justyna Śmiałek-Bartyzel (Institute of Nuclear Physics Polish Academy of Sciences, Poland)

Wednesday - October 2, 2024

Session III: Innovative ex-vivo cancer models

09:00 – 09:30	In vivo tumors & ex vivo tumoroids establish physics-driven genetic changes & tumoricidal macrophages Dennis Discher (University of Pennsylvania, USA)
09:30 – 10:00	Tissue slices and tissue slice tandem co-culture models: from ex vivo tumor studies towards specific inhibition of glioma invasion Achim Aigner (Leipzig University, Germany)
10:00 – 10:30	Coffee break
10:30 – 11:00	Prostate cancer associated fibroblasts have distinct morpho-mechanical features that are associated with patient outcome Anna Taubenberger (TU Dresden, Germany)
11:00 – 11:15	Collagen-hyaluronic hydrogels as a platform to study shear force impact on bladder cancer spheroids Sara Metwally (Institute of Nuclear Phisics Polish Academy of Sciences, Poland)
11:15 – 11:45	Modeling cell interactions in the tumor microenvironment Erik Danen (Leiden University, The Netherlands)
11:45 – 12:00	Confinement and mechanical stress may induce cell heterogeneity and polyploidy in 3D tumoral environments Aldo Leal-Egaña (Heidelberg University, Germany)
12:00 – 12:15	Growing tumor spheroids from single cells is associated with changes in cell volume and mechanical properties Vaibhav Mahajan (TU Dresden, Germany)
12:15 – 13:30	Lunch break
Session IV: Mechanical immune escape mechanisms

13:30 – 14:00	Keynote Speaker Mechanobiology of cytototoxic lymphocyte-mediated solid tumour rejection Maté Biro (EMBL, Australia)
14:00 – 14:30	Predicting safety and efficacy of engineered T cells using an ex vivo human model Emmanuel Donnadieu (Institut Cochin, France)
14:30 – 14:45	Effect of fibroblast contractility on immune infiltration in 3D co-culture spheroids of colorectal cancer Eleni Dalaka (Institute for Bioengineering of Catalonia (IBEC), Spain
14:45 – 15:15	Coffee break
15:15 – 15:45	3D Multi-omic cellular maps and CAR T cells engineered to infiltrate solid tumors Denis Wirtz (Johns Hopkins University, USA)
15:45 – 16:15	Understanding the link between immune evasion and metastasis: A story of stromal - immune cell interactions in tumor-draining lymph nodes Angela Riedel (University of Würzburg)
16:15 – 16:30	Precision and Personalized Adaptive Hormone Control of Metastatic Prostate Cancer Trung Phan (John Hopkins University, USA)
16:30 – 17:00	Immune cells employ intermittent integrin-mediated traction forces for 3D migration Christoph Mark (FAU Erlangen-Nuremberg, Germany)
17:00 – 17:30	Closing remarks & Young Scientist Awards