Poster

Nucleus position displacement in breast cancer cells

Jörg Walter¹, Pablo Gottheil¹, Axel Niendorf², Josef A. Käs¹

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The conventional view of the cell nucleus as a passive repository of genetic information has evolved significantly, with recent studies revealing its dynamic role in influencing various cellular functions. This presentation delves into the crucial aspect of nucleus positioning within breast cancer cells and its potential implications for metastases and other cellular functions.
The work focuses on the spatial arrangement of the nucleus within breast cancer cells from histological images by finding the theoretically most likely position of the nucleus and quantify the deviation of the real position from this geometrical model. Recognizing the dynamic nature of cell motility and its influence on nucleus positioning, this work incorporates these dynamic variations to provide a more comprehensive understanding of the factors influencing nucleus positioning in breast cancer cells.