Invited Talk

Intermediate filaments: from cell mechanics to glioblastoma invasion and therapeutic resistance

Insitute Pasteur, 25-28 Rue du Docteur Roux, 75015, Paris, France

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Glioblastoma multiforme is the most common and aggressive malignant brain tumor, characterized by a poor prognosis and the absence of curative therapies. The intratumoral heterogeneity and invasive behavior of glioblastoma cells significantly contribute to tumor aggressiveness and therapeutic failures. Cell invasion, a hallmark of cancer, is driven by cell intrinsic mechanical properties and mechanotransduction, a multi-step cellular and gene regulatory process that governs cellular responses to mechanical stimuli. Due to their physical properties, cytoskeletal components, including intermediate filaments are crucial in modulating cell mechanical and invasive properties, enabling tumor cells to respond to physical stresses encountered during cancer progression. In this presentation we will explore how variations in the expression of intermediate filament proteins participate in glioblastoma cell mechanics to influence cell invasive properties and resistance to treatment, highlighting potential therapeutic targets to improve patient outcomes.