Invited Talk

High resolution modeling of cell migration in the tumor immune ecosystem

MD Anderson Cancer Center, Houston, USA

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Cancer and immune cell migration are vital processes in the complex adaptive dynamic system of tumor growth. We developed a variety of low- and high-resolution modeling approaches to quantify the rate constants of the different involved mechanisms. On the sub-cellular and cellular level, we built a multi-scale hybrid continuous discrete agent-based modeling approach on two interacting lattices. This allows high-resolution analyses of the population level consequences of different biological rules, and how to best harness them for therapeutic intervention. On the tissue level, we use spatial statistics approaches on clinical biopsy data to infer what the underlying tumor growth dynamics are that lead to the specific spatial cell configurations. In combination, these approaches will help better understand the physics of tumor growth and treatment response.