12th Annual Symposium
Physics of Cancer
Leipzig, Germany
Aug 30 - Sept 1, 2021
Invited Talk
Geometric control of intestinal organoid patterning
Matthias Lütolf1,2
1Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, EPFL, Lausanne, Switzerland
2Roche Institute for Translational Bioengineering (ITB), Roche Innovation Center Basel, Switzerland
Contact:  | Website
Organoids form through poorly understood morphogenetic processes in which initially homogeneous ensembles of stem cells spontaneously self-organize in suspension or within permissive three-dimensional extracellular matrices. Yet, the absence of virtually any predefined patterning influences such as morphogen gradients or mechanical cues results in an extensive heterogeneity. Moreover, the current mismatch in shape, size and lifespan between native organs and their in vitro counterparts hinders their even wider applicability. In this talk, I will present some of our ongoing work to develop next-generation organoids that are built by controlling cellular self-patterning in artificial stem cell microenvironments. In particular, I will present some recent work in which we highlight the role of tissue geometry in patterning intestinal organoids.
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