12th Annual Symposium
Physics of Cancer
Leipzig, Germany
Aug 30 - Sept 1, 2021
Invited Talk
Correlations among substrate composition, cell motility, and stiffness in cancer and non-cancer cell lines
Paul Janmey1,2, Daniel Iwamoto1, Jonathan Nukpezah2, Ravi Radhakrishnan2
1Institute for Medicine and Engineering, Dept. of Physiology, University of Pennsylvania, USA
2Dept. of Bioengineering, University of Pennsylvania, USA
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The US National Cancer Institute established the Physical Sciences in Oncology Network (PS-ON) Bioresource Core Facility to create a panel of model human, immortalized cell lines (https://physics.cancer.gov/bioresources/). The PBCF includes 30 authenticated non-malignant and cancerous cell lines from a variety of tissue types for which the physical phenotype was characterized by measurements of area, circularity, aspect ratio, volume, stiffness, contractile force, and motility (speed and persistence) on seven different substrates that differ by stiffness and chemical composition. These data revealed some previously reported correlations between several pairs of physical parameters, but also revealed novel patterns such as the similar effects of substrate stiffness and combination of hyaluronan and integrin ligands on soft substrates. Principle component analysis and machine learning methods reveal further patterns in the physical characteristics that distinguish malignant from nonmalignant cell types.
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