12th Annual Symposium
Physics of Cancer
Leipzig, Germany
Aug 30 - Sept 1, 2021
Invited Talk
Using tumor biomechanics to better understand tumor response to therapy
Marvin Doyley
University of Rochester, Dept. of Electrical and Computer Engineering, 518 Computer Science Building Rochester NY 14627, USA
Contact:  | Website
Patients with pancreatic cancer has a 5-year survival rate of less than 10%. Currently, surgical resection is the most effective therapy, but only 15-20% of pancreatic cancer patients have resectable disease at diagnosis. For patients with borderline resectable tumors, neoadjuvant therapies can downstage the tumor and enable surgical resection. However, the tumor microenvironment (TME) limits the ability of neoadjuvant therapies to do so. Conventional imaging modalities (X-ray CT or MRI) provides information about major blood vessels and soft tissue geometry, but they do not provide information about tumor microenvironmental changes. To improve this situation, we have been investigating if shear modulus (SM) and vascular perfusion (VP) can provide real-time information the tumor response to Stereotactic body radiation therapy (SBRT) neoadjuvant therapies. In this talk we will report the results of preclinical studies performed with murine pancreatic tumor to assess how shear modulus impacts the delivery of chemotherapy agents to the tumor parenchyma and how well SBRT modulus shear modulus. We will also report the results of studies that demonstrate that the biomechanical properties of radiation-responsive tumors are different from their non-responsive counterpart.
University of Leipzig  |  Faculty of Physics and Earth Sciences  |  Peter Debye Institute  |  Soft Matter Physics Division
© Soft Matter Physics Division, University of Leipzig. Designed and created by sp design. Imprint & Disclaimer