12th Annual Symposium
Physics of Cancer
Aug 30 - Sept 1, 2021
|PoC - Physics of Cancer - Annual Symposium|
Tomoelastography in biomechanical characterization of cancer in vivo
Department of Radiology, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Today diagnostic imaging such as MRI is the key examination tool for locating tumours, assessing tumorigenic stages and planning therapy in cancer. However, standard routine MRI is sometimes limited for predicting a patient’s individual outcome and the risk of aggressive tumor progression. The importance of mechanical cell–matrix interactions for the development, progression and spread of cancer has long been recognised. Altered collagen content and alignment translates to macroscopic changes in biomechanical tissue properties that can be non-invasively quantified in vivo by tomoelastography, an advanced magnetic resonance elastography (MRE) technique that includes multiple actuators operated by compressed air, multifrequency MRE, and noise-robust data processing. Tomoelastography provides elastograms that depict anatomical features and small lesions with high resolution and precision. Additionally, tomoelastography delivers independent biomechanical parameters such as stiffness, viscosity, and fluidity which reveal the deep connection between cancer biology and tissue biomechanics and can be integrated into the scope of multiparametric MRI thereby offering a quantitative, biophysical imaging marker sensitive to the collective properties of cancer cells in vivo.