9th Annual Symposium
Physics of Cancer
September 24-26, 2018
|PoC - Physics of Cancer - Annual Symposium|
Control of mechanosensitivity by integrin-ECM binding and nucleocytoplasmic shuttling kinetics
Institute for Bioengineering of Catalonia, Parc Científic de Barcelona (PCB): Edifici Hèlix c/ Baldiri Reixac 15-21 08028 Barcelona, Spain
Contact: | Website
Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the rigidity of the extracellular matrix (ECM). In this talk, I will explain how we combine molecular biology, biophysical measurements, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix rigidity. I will discuss how the properties under force of integrin-ECM bonds, and of the adaptor protein talin, drive and regulate rigidity sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model, which can quantitatively predict the role of integrins, talin, myosin, and ECM receptors, and their effect on cell response. Finally, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus, leading to the activation of the transcriptional regulator YAP.