9th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 24-26, 2018
Invited Talk
Modulation of cortical actin assembly dynamics
Anne-Cécile Reymann
IGBMC - CNRS UMR 7104 - Inserm U 1258, 1 rue Laurent Fries, BP 10142 67404 Illkirch Cedex, CU Strasbourg, France
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The cortex is a thin layer of actin filaments attached to the cellular membrane controlling the form and movement of cells through a constant remodeling of its network of filaments. This architecture is modulated by a combination of specific signaling pathways, numerous regulatory proteins, but is also modified through feedbacks with the mechanical properties and dynamics of this gel like material. As a result, the cortical layer is spatially and temporally regulated.

By the use of in vivo endogenous labeling of proteins and state of the art microscopes, we are now able to resolve the dynamics molecular components of the cytoskeleton in the cortical layer of C. elegans embryos. For example, how fast a formin elongates actin filaments or where capping protein blocks these growing ends. We have also investigated how myosin-induced cortical flows directly drive filaments alignment in contractile rings to induce a stable ingression by mechanically remodeling the actin architecture. This brings up the question of the contribution of the mechanics during this initial phase of contractile ring assembly.
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