6th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 7-9, 2015
Invited Talk
Role of differential physical properties in emergent behavior of 3D cell co-cultures
Moumita Das
Rochester Institute of Technology, One Lomb Memorial Drive, Rochester, NY 14623-5603, USA
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The biophysics of binary cell populations is of great interest in many biological processes, whether the formation of embryos or the initiation of tumors [1]. During these processes, cells are surrounded by other cell types with different physical properties, often with important consequences. For example, recent experiments on a co-culture of breast cancer cells and healthy breast epithelial cells suggest that the mechanical mismatch between the two cell types may contribute to enhanced migration of the cancer cells [2]. Here we explore how the differential physical properties of different cell types may influence cell-cell interaction, aggregation, and migration. To this end, I will discuss our investigations of a proof of concept model-- a three-dimensional binary system of interacting, active, and deformable particles with different physical properties such as elastic stiffness, contractility, and cell-cell adhesion, using Langevin Dynamics simulations. Our results may provide insights into emergent behavior such as segregation and differential migration in cell co-cultures in three dimensions.
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