6th Annual Symposium
Physics of Cancer
September 7-9, 2015
|PoC - Physics of Cancer - Annual Symposium|
Role of differential physical properties in emergent behavior of 3D cell co-cultures
Rochester Institute of Technology, One Lomb Memorial Drive, Rochester, NY 14623-5603, USA
Contact: | Website
The biophysics of binary cell populations is of great interest in many biological processes, whether the formation of embryos or the initiation of tumors . During these processes, cells are surrounded by other cell types with different physical properties, often with important consequences. For example, recent experiments on a co-culture of breast cancer cells and healthy breast epithelial cells suggest that the mechanical mismatch between the two cell types may contribute to enhanced migration of the cancer cells . Here we explore how the differential physical properties of different cell types may influence cell-cell interaction, aggregation, and migration. To this end, I will discuss our investigations of a proof of concept model-- a three-dimensional binary system of interacting, active, and deformable particles with different physical properties such as elastic stiffness, contractility, and cell-cell adhesion, using Langevin Dynamics simulations. Our results may provide insights into emergent behavior such as segregation and differential migration in cell co-cultures in three dimensions.