6th Annual Symposium
Physics of Cancer
September 7-9, 2015
|PoC - Physics of Cancer - Annual Symposium|
Jamming as a key factor in tumor progression
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When cancer cells are mixed with normal cell they self-organize in a tumour spheroid surrounded by normal cells. This cell aggregation in tumours is not driven by differential adhesion. Cell jamming is a key factor that stabilizes the tumour boundary. The epithelial mesenchymal transition (EMT) can be described as an unjamming transition alike a solid to fluid transition in glasses. Cell softening in rigid tumours triggers the formation of channels for cellular streaming. The mechanical alterations to a tumour’s microenvironment are a measure for the barrier strength and spatial sharpness of a tumour boundary.