6th Annual Symposium
Physics of Cancer
Leipzig, Germany
September 7-9, 2015
Invited Talk
Jamming as a key factor in tumor progression
Josef A. Käs1, Steve Pawlizak1, Anatol Fritsch1, Steffen Grosser1, Linda Oswald1, Franziska Wetzel1, Michael Höckel1, Lars Christian Horn1, Max Dapeng2, Cristina Marchetti2, Lisa Manning2
1University of Leipzig, Leipzig, Germany
2University of Syracuse, Syracuse, USA
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When cancer cells are mixed with normal cell they self-organize in a tumour spheroid surrounded by normal cells. This cell aggregation in tumours is not driven by differential adhesion. Cell jamming is a key factor that stabilizes the tumour boundary. The epithelial mesenchymal transition (EMT) can be described as an unjamming transition alike a solid to fluid transition in glasses. Cell softening in rigid tumours triggers the formation of channels for cellular streaming. The mechanical alterations to a tumour’s microenvironment are a measure for the barrier strength and spatial sharpness of a tumour boundary.
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