8th Annual Symposium
Physics of Cancer
Leipzig, Germany
October 4-6, 2017
Invited Talk
Integrating Scales in Cancer Mechanobiology: The NCI Physical Sciences – Oncology Network
Nastaran Zahir
Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA
Contact:  | Website
The U.S. National Cancer Institute (NCI) leads, conducts, and supports cancer research across the nation to advance scientific knowledge and help all people live longer, healthier lives. Since 2009, the NCI has supported the NCI Physical Sciences – Oncology Network (PS-ON) program that aims to better understand the emergence and behavior of cancer through the perspective of the physical laws and principles that shape and govern this disease. The transdisciplinary PS-ON teams integrate physical sciences perspectives with cancer research to complement and expand on our current understanding of cancer across many biological length- and time-scales. Thematic areas under investigation in the PS-ON include transcriptional dynamics and genomic architecture, modeling evolutionary dynamics of treatment response, cancer mechanobiology and the physical microenvironment, and multi-scale computational modeling approaches to integrate data across length scales. In this presentation, projects examining aspects of cancer mechanobiology will be described to highlight the transdisciplinary physical oncology approaches and perspectives towards understanding the interplay between the physical microenvironment and tumor and stromal cells in primary and metastatic disease.
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