8th Annual Symposium
Physics of Cancer
October 4-6, 2017
|PoC - Physics of Cancer - Annual Symposium|
Physical forces driving migration, division and folding of epithelial sheets
Institute for Bioengineering of Catalonia (IBEC), Edifici Clúster c/ Baldiri Reixac 10-12 08028 Barcelona, Spain
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Biological processes such as morphogenesis, tissue regeneration, and cancer invasion are driven by collective migration, division, and folding of epithelial tissues. Each of these functions is tightly regulated by mechanochemical networks and ultimately driven by physical forces. I will present maps of cell-cell and cell-extracellular matrix (ECM) forces during cell migration and division in a variety of epithelial models, from the expanding MDCK cluster to the regenerating zebrafish epicardium. These maps revealed that migration and division in growing tissues are regulated cooperatively. I will also present direct measurements of epithelial traction, tension, and luminal pressure in three-dimensional epithelia of controlled size and shape. By examining epithelial tension over time-scales of hours and for nominal strains reaching 300%, we establish a remarkable degree of tensional homeostasis mediated by cellular adaptations.