8th Annual Symposium
Physics of Cancer
Leipzig, Germany
October 4-6, 2017
Invited Talk
Strain-controlled rigidity transitions in cells and the role of the cell nucleus
Jennifer Schwarz
Syracuse University, College of Arts and Sciences, Department of Physics, Syracuse, NY 13244, USA
Contact:  | Website
What happens to a stationary cell when it is squeezed at large strains? Does the cell become more rigid mechanically, i.e. compression stiffen? Or does it yield and become floppy? Since the cellular cytoskeleton gives the cell structural support and the cytoskeleton is composed of semiflexible polymers that can buckle, i.e. yield, then one might conclude that the cell softens as it is squeezed. I, however, will present modeling demonstrating compression stiffening in cells using rigidity transitions as a framework and show how mechanical coupling between the cellular cytoskeleton and the nuclear cytoskeleton affects the stiffening. ​
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