8th Annual Symposium
Physics of Cancer
October 4-6, 2017
|PoC - Physics of Cancer - Annual Symposium|
Physical aspects of successful cell circulation and migration
TU Dresden Biotec, Tatzberg 47/49, 01307 Dresden, Germany
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It is often repeated as a matter of fact that cancer cells, and in particular metastatic cancer cells, are more compliant than their healthy counterparts so that they can better spread through the body to form metastases. Our research over the last years has shown on the one hand that there is at least one exception to the general finding that cancer cells are more compliant. In the hematopoietic system, the leukemic blast cells are actually stiffer than the healthy mature blood cells. On the other hand, we have also shown that the seemingly obvious connection between cell compliance and improved spreading has to be modified, especially considering the timescales involved in the mechanical probing as they relate differently to cell circulation through the vasculature and to migration through tissue. Considering these aspects, cell properties can be tuned to improve circulation characteristics, for example in the use of mesenchymal stromal cells for immunomodulation during transplantation to suppress graft-vs-host-disease. Overall, there is an emergent consistent view of the importance of these physical properties for a better understanding of how cells spread and as possible targets to prevent disease.