7th Annual Symposium
Physics of Cancer
October 4-6, 2016
|PoC - Physics of Cancer - Annual Symposium|
Investigating Heterogeneity of Tumor Mechanical Properties with Super-Resolution Multifrequency Magnetic Resonance Elastography
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Tumorigenesis is sensitive to tissue spatial structures and tissue mechanical parameters. Magnetic Resonance Elastography (MRE) is an MRI-based method of measuring gross-scale soft tissue mechanical properties such as elasticity and viscosity. In MRE, simultaneous with an MRI scan acquisition, soft tissue of interest is vibrated with steady state waves, and the waves are encoded in the MRI phase image, enabling determination of wave speed and damping by wave inversion. MRE viscoelasticity maps have been shown to be sensitive to alterations in tissue microstructure and to mechanical pressures. Recently, multifrequency MRE (MMRE), which exploits wave scaling properties across MRE scans at multiple frequencies, was shown to enable super-resolution.
In this initial investigation, elasticity images of glioblastoma and metastases patients were acquired with MMRE, and for the first time, super-resolved. In our initial findings, mechanical property maps of the tumours revealed heterogeneities not visible in the conventional-resolution acquisitions, as well as sharply resolved spatial boundaries. The dual-parameter inversion enables a rich characterisation of the mechanical properties of these newly visible details.