7th Annual Symposium
Physics of Cancer
October 4-6, 2016
|PoC - Physics of Cancer - Annual Symposium|
Measuring and Modeling Collective Cell Migration
University of Maryland, Department of Physics, Physical Sciences Complex, College Park, MD 20742, U.S.A.
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The metastatic process begins when cells migrate away from the primary tumor in small groups. Thus the long process of metastasis starts with changes in the collective behavior of primary tumor cells. I will describe our recent effort to capture and measure these changes in collective migration using metrics that capture a broad range of lengthscales and timescales. By analyzing migration dynamics from multiple scales and perspectives, we are able to make a clear comparison of our experimental results to a simulation of collective cell migration, and provide a nuanced phenotype of collective behavior. To further elucidate basic mechanisms that can underly collective behavior, we analyze how changes in cytoskeletal dynamics, cell cell adhesion and cell-substrate adhesion alter collective cell migration in a simple cell model system.