6th Annual Symposium
Physics of Cancer
September 7-9, 2015
|PoC - Physics of Cancer - Annual Symposium|
Magnetic resonance elastography: Towards high resolution scans of soft tissue viscoelasticity in radiological routine
Charité Berlin, Institut für Radiologie, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany
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Palpation is one of the most sensitive and most effective diagnostic practices and has motivated the use of high-end medical imaging modalities for the stiffness-based detection of diseases. However, this so-called elastography suffers from limited anatomical resolution, currently precluding its use as a tomographic modality on its own. We here show that the anatomy of elasticity is a uniquely rich and unexplored source of MRI contrast, which can be retrieved by combining multiple inversions of harmonic wave fields and noise-robust wave number analysis. Using ultrafast motion-sensitive MRI of abdominal organs, we demonstrate that novel tomographic elastography reveals variations in tissue structures with high spatial resolution to the naked eye. Overall, multiharmonic wave number-reconstruction in elastography opens a tomographic window into soft tissue anatomy related to elasticity and viscosity, thereby paving the way for biophysically based quantitative detection and staging of diseases in clinical radiology.