6th Annual Symposium
Physics of Cancer
September 7-9, 2015
|PoC - Physics of Cancer - Annual Symposium|
Fibril-like environments arbitrate migratory transitions
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Cellular microenvironments mimicking the fibrillar structure of the natural extracellular matrix favour single cell release from an endothelial monolayer within a well-defined dimensional range and in a confinement-dependent manner. The frequency of endothelial single cell migration escape events from the monolayer and the mode of migration changes with fibril width. The cell body and the nucleus dimensions adapt to the geometry of the migration space, with an actomyosin-dependent contraction mechanism. The cell nucleus shrank under confinement to dimensions at which a transition between mesenchymal and amoeboid migration modes was observed. Matrix fibrillar morphology plays a key role in arbitrating endothelium migration, which can be critical during fibrosis and tumor development.