The scientific program consists of invited and contributed talks as well as a poster session. All participant will receive a printed program booklet containing the detailed schedule including all abstracts at the conference. You may also download this program booklet as PDF file. However, please pay attention to our constantly updated web schedule below accounting for last-minute rearrangements. Particularly, due to the impact of hurricane Sandy, some schedule changes regarding talks of speakers from the USA might become necessary. Talks: All talk sessions take place at Center for Biotechnology and Biomedicine (BBZ) in the large auditory (ground floor, SR 1.1 to 1.3). Contributed talks are allocated 15 min (including discussion), whereas invited talks are allocated 20 min plus 10 min discussion. Posters: The session for poster presentation is on Thursday, November 1, 2012 at 19:00 at Center for Biotechnology and Biomedicine (BBZ) in the foyer. During this session snacks and fingerfood will be provided for all. The poster boards will be marked with the number according to the scientific program. Posters must fit within a rectangle 90 cm wide and 120 cm high (DIN A0), portrait format. The material necessary to mount the poster (pins or "Poster Strips") will be provided.

 

13:00 – 13:15	Welcome / Opening Beate A. Schücking (Rector of the University of Leipzig)
Session I: Biomechanics of Cell Adhesion and Gene Expression
13:15 – 13:45	Do tumor cells care about physics? Josef A. Käs (University of Leipzig, Germany)
13:45 – 14:15	Active cell shape control by contractile actin-myosin networks Gijsje Koenderink (FOM Institute AMOLF, The Netherlands)
14:15 – 14:45	Force-dependent and -independent integrin regulation of ROS-production Staffan Johansson (Uppsala University, Sweden)
14:45 – 15:15	Coffee break
15:15 – 15:45	Extracellular matrix models and the cytoskeleton Florian Rehfeldt (Georg August University of Göttingen, Germany)
15:45 – 16:15	Surface changes on dying tumor cells instruct the immune system Martin Herrmann (University Hospital Erlangen, Germany)
16:15 – 16:45	The keratin desmosome connection: Crucial player in tissue integrity and malignancy Thomas M. Magin (University of Leipzig, Germany)
16:45 – 17:15	Reprogramming cellular mechanosensing by hyaluronic acid and its receptors Paul Janmey (University of Pennsylvania, USA)
17:15 – 17:30	Higher ordered actin bundle assembly induced by counterions and crowding agents Jörg Schnauß (University of Leipzig, Germany)
17:30 – 17:45	Quantification of live keratin network dynamics Marcin Moch (RWTH Aachen University, Germany)
17:45 – 18:00	Keratins are major determinants of migration and invasion by influencing adhesion and cell stiffness Kristin Seltmann (University of Leipzig, Germany)
Poster Session
19:00	01	Native root extract of Linum usitatissimum induces cytoskeletal remodeling in the breast cancer cell line MCF-7 Nadja Engel (University of Rostock, Germany)
	02	The role of cellular adhesion for compartmentalization and its impact on tumor spreading Steve Pawlizak (University of Leipzig, Germany)
	03	Binding of hyaluronan to sulfated glycosaminoglycans in CD44 Maria Schönberg (University of Leipzig, Germany)
	04	Quantitative characterization of biomaterials and their interaction with living cells by AFM Torsten Müller (JPK Instruments AG, Germany)
	05	3D topology of tumor cell colonies on 2D substrates Janina Lange (University of Erlangen-Nuremberg, Germany)
	06	Blood platelets- a model system for understanding cellular mechanics Aishwarya Paknikar (Georg August University of Göttingen, Germany)
	07	Modulation of cell adhesion by non-covalently attached ligands Andreas Müller (University of Leipzig, Germany)
	08	Circular ruffle dynamics on fibroblast cells Erik Bernitt (University of Bremen, Germany)
	09	Cell adhesion on different materials in the presence or the absence of fetal bovine serum Martina Verdanova (Charles University Prague, Czech Republic)
	10	Blood platelets as a model system for cell substrate interactions Rabea Sandmann (Georg August University of Göttingen, Germany)
	11	Inherently slow and weak forward forces of neuronal growth cones measured by a drift-stabilized atomic force microscope Thomas Fuhs (University of Leipzig, Germany)
	12	Mechanics of collagen gels – what cells feel Julian Steinwachs (University Erlangen-Nuremberg, Germany)
	13	The evolution of collagen mechanics in response to large amplitude loading Stefan Münster (University Erlangen-Nuremberg, Germany)
	14	The nanomechanical signature of breast cancer Marija Plodinec (University of Basel, Switzerland)
	15	ß1 integrins restrict the growth of foci and spheroids Rajesh Gupta (Uppsala University, Sweden)
	16	Sensitive control of active gel contraction Felix Keber (TU Munich, Germany)
	17	Virtual probing of cells with microscopic imaging and computational modeling Evgeny Gladilin (German Cancer Research Center, Heidelberg, Germany)
	18	Biomechanical studies on human primary cervix cells Anatol Fritsch (University of Leipzig, Germany)

 

Session II: Cell Migration and Forces I
08:30 – 09:00	The role of mechano-sensing and matrix geometry in cancer invasion Erik Sahai (London Research Institute, UK)
09:00 – 09:30	Spatially and temporally coordinated processes of cells at molecular to cellular scales Joachim P. Spatz (Max Planck Institute for Intelligent Systems, Germany)
09:30 – 10:00	Assembly and role of the nuclear intermediate filament proteins for nuclear structure and stability Harald Herrmann (German Cancer Research Center, Heidelberg, Germany) Mechanical regulation of tumor reversion Daniel A. Fletcher (University of California, Berkeley, USA)
10:00 – 10:30	Coffee break
10:30 – 11:00	Biomechanical properties of cancer cells determine their aggressiveness Claudia T. Mierke (University of Leipzig, Germany)
11:00 – 11:30	Self-organization of the actin cytoskeleton: Physical mechanisms and signaling pathways Alexander Bershadsky (Weizmann Institute of Science, Israel)
11:30 – 12:00	Mechanical regulation of adhesive bonds David E. Boettiger (University of Pennsylvania, USA)
12:00 – 12:15	The percolation transition of transportation networks as a universal gauge for tumor vascularization Hans-Günther Döbereiner (University of Bremen, Germany)
12:15 – 12:30	Forces in cellular growth and division Jörn Hartung (Max Planck Institute for Dynamics and Self-Organisation, Göttingen, Germany)
12:30 – 14:30	Lunch break
Session III: Cell Migration and Forces II
14:30 – 15:00	Significance of the mechanical properties of the cell nucleus in cell migration and transit through narrow constrictions Jan Lammerding (Cornell University, USA)
15:00 – 15:30	Predictive mechanical models for dynamic tissue remodeling M. Lisa Manning (Syracuse University, USA)
15:30 – 15:45	Assembly of cytoplasmic intermediate filament proteins Norbert Mücke (German Cancer Research Center, Germany)
15:45 – 16:00	In vivo imaging of lysyl oxidase by fluorine-18 labeled substrate-based radiotracers Manuela Kuchar (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
16:00 – 16:15	Temperature-dependent assembly properties of keratin 8/18 Ines Martin (Ulm University, Germany)
16:15 – 16:30	Optical breast tissue pre-screening for the identification of cancer risk and presence of malignancies Lothar Lilge (University of Toronto, Canada)
16:30 – 17:00	Coffee break
17:00 – 17:30	Boron clusters in cancer therapy Evamarie Hey-Hawkins (University of Leipzig, Germany)
17:30 – 18:00	Beyond conventional limits to cancer: Where can a physical sciences perspective fit in? Larry A. Nagahara (National Cancer Institute, USA)
19:00	Get together for invited speakers

 

Session IV: Membrane Mechanics, Cytoskeletal Dynamics, and Tumor Progression
08:00 – 08:30	Mechanics of contractile actomyosin bundles Philippe Marcq (Institute Curie, France)
08:30 – 09:00	Mechanosensitivity and motility of cellular aggregates Françoise Brochard-Wyart (Institute Curie, France)
09:00 – 09:30	Extrinsic and intrinsic force regulation of tumor progression Valerie M. Weaver (University of California, San Francisco, USA)
09:30 – 10:00	The nanomechanical signature of breast cancer Roderick Y. H. Lim (University of Basel, Switzerland)
10:00 – 10:15	Nonlinear fibrin mechanics and its alterations by platelets Louise Jawerth  (Harvard University, USA)
10:15 – 10:45	Coffee break
10:45 – 11:15	Dynamic motility and F-actin network structure: Insights from mathematical modeling Martin Falcke (Max-Delbrück-Center for Molecular Medicine, Mathematical Cell Physiology, Germany) Coordination of locomotory and invasive protrusions during migration and dissemination of tumor cells in breast tumors John S. Condeelis (Albert Einstein College of Medicine, USA)
11:15 – 11:45	Regulation of focal adhesion maturation by the actin cytoskeleton Margaret Gardel (University of Chicago, USA)
11:45 – 12:15	Cell motility and cytoskeleton assembly Julie Plastino (Institute Curie, France)
12:15 – 12:45	Ruthenium(II) polypyridyl complexes as carriers for DNA delivery Avinash S. Kumbhar (University of Pune, India)
12:45 – 13:15	Lamin-A levels limit 3D-migration but protect against migration-induced apoptosis Dennis E. Discher (University of Pennsylvania, USA)
13:15 – 13:30	Prospective end