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The determinants of this remodeling process involve the morphological and hydrodynamic properties of the initial network, generation of new vessels (sprouting angiogenesis), vessel dilation (circumferential growth), blood flow correlated vessel regression, tumor cell proliferation and death, and the interdependence of these processes via spatio-temporal changes of blood flow parameters, oxygen / nutrient supply and growth factor concentration fields. The emerging tumor vasculature is non-hierarchical and compartmentalized into different zones. It displays a complex geometry with necrotic zones and "hot spots" of increased vascular density and blood flow of varying size. The model allows to reveal the physical origin of geometric and morphological features and predicts the large scale patterns of blood and interstitial fluid flow and its influence on drug delivery. |
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