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| Influence of cell cycle stage
on the optical deformability of cells
Susanne Rönicke, Roland Stange,
Josef A. Käs
University of Leipzig, Faculty of
Physics and Earth Sciences, Institute of Experimental Physics I, Soft Matter
Physics Division, Linnéstraße 5, 04103 Leipzig, Germany |
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During the four stages of cell cycle cells undergo many structural and
organizational changes which can have a possible influence on their biomechanics.
To investigate whether such changes are large enough to notably change
the optical deformability, cells were marked with fluorescent cell cycle
markers and measured in the optical stretcher which was modified for automated
fluorescence measurements. The used cell cycle marker allows a distinction
between cells in G1 phase, S phase, and G2 phase.
First results do not show a significant change in optical deformability
at low stretching powers for cells in G1 phase compared to G2
phase and therefore cannot explain the asymmetric distribution of deformability
within cell populations.
Fig. 1: Cell cycle stages
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