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| Invited Talk, Friday, 09:30 – 10:00 |
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| Intracellular pattern generation
- mechanics meets biochemistry
Stephan W. Grill
Max Planck Institute of Molecular
Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden,
Germany |
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| Contact:
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I will present recent advances in our understanding of the coupling of
mechanical and biochemical processes for the purpose of forming intracellular
patterns. I will begin by discussing in general terms the mechanism of
pattern formation in active fluids in which active stress is regulated
by diffusing molecular components. I will then discuss a particular biological
example, which is the polarization of the C. elegans zygote, a classic
example for mechanochemical coupling. I illustrate how passive advection
by actively generated fluid flow is sufficient to drive asymmetry in PAR
proteins and thereby acts as a trigger for pattern formation. Our work
suggests that passive advective transport in a regulated active material
is a general mechanism by which patterns are established in developmental
biology. |
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