| Invited Talk, Friday, 16:45 – 17:15 |
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| Tissue Simulations - Numerical
methods for tissue growth
Jens Elgeti
Physical Approach of Biological Problems,
Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France |
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| Contact:
| Website |
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From a physics perspective, tissues can be regarded as an active material:
A material that can grow. Over the past decades the notion that physics,
and in particular mechanics plays an important role in growth dynamics
has evolved from hypothesis to fact.
Even though an increasing number of experiments and theoretical works
have focused on this puzzle, and many pieces have been found, we are still
far from seeing the whole picture.
In this work we want to shed a light on the basic mechanical properties
we expect from a tissue. We model biological tissues using a simple, mechanistic
simulation based on dissipative particle dynamics. We investigate the continuum
behavior of the simulated tissue and determine its dependence on the properties
of the individual cell.
Consistent with continuum theory predictions, we identify a mechanic
factor for competitive growth: The homeostatic pressure. In close collaboration
with experiments, we study the effect of pressure on growth. Furthermore
we show that cell turnover fluidifies a tissue and thus behaves liquid
like on long time scales. |
