Cytoskeletal filaments - new
treatment targets in cancer?
Michael Beil
University of Ulm, University Hospital,
Center for Internal Medicine, Clinic for Internal Medicine I, Albert-Einstein-Allee
23, 89081 Ulm, Germany
Contact:
The fundamental role of the cytoskeleton for regulating cell shape and
mechanics has been emphasized by a large number of experimental studies.
Cytoskeletal filament systems could become a prime target for blocking
cancer cell migration. However, the success story of taxol targeting microtubules
in-vivo has not been duplicated so far by developing clinically useful
agents which interfere with other filament systems. The particular contributions
of and the interplay between the major components of the cytoskeleton remain
to be elucidated in more detail. This talk will discuss new developments
in this field and demonstrate strategies to target cancer cell motility.
